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Celebrex

Marketed by Pfizer, Celebrex is a prescription medication that has been indicated to treat pain and inflammation caused due to conditions like rheumatoid arthritis, ankylosing spondylitis and osteoarthritis. This is a non-steroidal anti-inflammatory drug that relieves pain and inflammation without causing any harmful effect on the digestive tract. Approved by the majority of the drug regulatory authorities, Celebrex is the most preferred pain relieving drug compared to other NSAIDs. Celebrex works by blocking the action of enzyme that causes pain and inflammation in response to the injury and diseases. Patients recommended with Celebrex must remember that this drug is not a cure of arthritis but it only manages and control the symptoms associated with arthritis.

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Celebrex Composition

Celecoxib is the active ingredient in Celebrex. The inactive ingredients used in the drug include magnesium stearate, povidone, edible inks, gelatin, lactose monohydrate, croscarmellose sodium and sodium lauryl sulfate.

Celecoxib Working Mechanism

COX-1 and COX-2 are the two different types of enzyme present in the body. COX-2 enzyme produces prostaglandins in response to injury or disease that causes pain, swelling and inflammation in the body. COX-1 is a useful prostaglandin that is involved in maintaining a healthy stomach and intestinal lining. Thus, Celecoxib works by blocking the action of COX-2 enzyme that produces prostaglandins which causes pain, swelling and inflammation in the body. Celecoxib is preferred over other anti-inflammatory drugs because of the fact that it is found effective in treating pain and inflammation by blocking only COX-2 enzyme. Unlike other anti-inflammatory drugs, Celebrex doesn’t block useful prostaglandin COX-1 and thus is less likely to cause gastro-intestinal side effects such as ulcers.