Antidepressants may be less effective with co-administration of anti-inflammatory drugs
Healthcare providers who prescribe antidepressants are advised to discourage patients from using anti-inflammatory drugs.
Healthcare providers who prescribe antidepressants are advised to discourage patients from using anti-inflammatory drugs. People who buy Zyprexa and other medications for mental illnesses should steer clear of ibuprofen, aspirin and naproxen, as these products may reduce the effectiveness of their depression medication.
Researchers from the Fisher Center for Alzheimer's Disease Research at Rockefeller University, who published their paper in the journal Proceedings of the National Academy of Sciences, reported that anti-inflammatory drugs can counteract the effects of antidepressants such as selective serotonin reuptake inhibitors (SSRIs).
"The mechanism underlying these effects is not yet clear," said lead author Jennifer Warner-Schmidt. "Nevertheless, our results may have profound implications for patients, given the very high treatment resistance rates for depressed individuals taking SSRIs."
Her colleague, Paul Greengard, added that physicians should carefully weigh the advantages and disadvantages of continuing anti-inflammatory therapy in patients who have been prescribed antidepressants.
In their study, they found that 54 percent of depressed individuals who did not use anti-inflammatory drugs responded better to antidepressants, compared to only 40 percent of people who did use anti-inflammatory products.
These findings may be significant for doctors who have recommended that individuals buy Zyprexa and other medications to treat mental illness.
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