Cancer finds alternate means of survival when faced with hormone ablation therapy, study shows
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UCLA researchers from the Jonnson Comprehensive Cancer Center recently found that blocking a common type of prostate cancer with hormone ablation therapy resulted in the tumor finding an alternate means of spreading. The cancer cells compensated by activating a survival cell signaling pathway, which enabled it to continue proliferating.
Lead author Hong Wu and his team published their findings in the current issue of the journal Cancer Cell.
"The most significant take-home message from this study is that certain prostate cancers can resist androgen deprivation therapy by activating an alternate pathway to drive their growth," Wu explained. "These two pathways are talking to each other, almost like regulatory circuitry, and helping each other get around attempts to kill the cancer."
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