Genetic rearrangements responsible for solid tissue malignancies also tied to breast cancer
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If American patients who have certain types of breast cancer are worried about the cost of treating their illness, they may find relief if they buy Canadian Tamoxifen at a fraction of the cost. Scientific research continues to uncover the various genes that influence the development of this disease, including two genetic rearrangements that were previously tied to cancers of the blood, prostate, lungs and other tissues.
Researchers from the University of Michigan Comprehensive Cancer Center sequenced the genes of 89 individual breast cancer cell lines. Results suggest a link between variations of MAST kinase and Notch family genes, and 5 to 7 percent of malignancies.
"What's exciting is that these gene fusions and rearrangements can give us targets for potential therapies," said researcher Arul Chinnaiyan, M.D., Ph.D. "This is a great example of why treating cancer is so challenging. There are so many different ways genes get recombined and so many molecular subtypes, that there's not one solution that will work for all of them."
When these rearrangements were introduced into normal cells, cancer began to develop, the researchers wrote in Cancer Medicine.
Furthermore, finding these genetic variations in individuals may support the concept of personalized medicine by indicating whether one patient's disease will respond to certain treatments, the researchers said.
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