HDAC inhibitors may prevent heart failure due to hypertension
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Individuals who have high blood pressure may find significant discounts on the products they need by purchasing cheap medication from Canada. Recently, researchers from the University of Texas Southwestern Medical Center discovered that a cancer treatment drug - which is a type of histone deacetylase (HDAC) inihibitor - could restore cardiac function and prevent heart failure caused by hypertension.
Lead investigator Joseph Hill and his colleagues published their findings in the journal Proceedings of the National Academy of Sciences. Their research was funded by the National Institutes of Health, the American Heart Association and the American Diabetes Association.
The research team reported that HDAC inhibitors have been shown to prevent autophagy - a process by which cells consume their own proteins during times of stress - in the heart muscle of laboratory mice.
"This opens the way for a new therapeutic strategy in hypertensive heart disease, one we can test for the potential to promote the regression of heart disease," Hill explained. "This is one of those exciting but rare examples where an important finding made originally in yeast moved into mouse models, and is soon moving to humans."
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