High-fat diets can lead to thickening of heart wall, reducing blood pumping efficiency
Many people are aware that a high-fat diet is not conducive to heart health, which is why those who consume such foods may want to buy Lipitor to reduce their risk of experiencing a heart attack.
Many people are aware that a high-fat diet is not conducive to heart health, which is why those who consume such foods may want to buy Lipitor to reduce their risk of experiencing a heart attack.
Recently, a paper published in the Journal of Biological Chemistry revealed that mice fed an unhealthy diet experienced thickening of the cardiac muscle, increasing the likelihood of heart failure.
Lead author Mitchell Lazar and his team explained that there is a molecular link between fat intake and an enzyme called HDAC3 that is responsible for regulating gene expression. Changing the activity of HDAC3 could be a lucrative pharmaceutical target.
"HDAC3 is an intermediary that normally protects mice from the ravages of a high-fat diet," Lazar explained.
They gave the high-fat diet to mice that lacked this enzyme, which eliminated its protective effects against the thickening of the cardiovascular walls. This essentially reduced the pumping efficiency of the organ, leading to the possibility of heart failure.
According to the scientists, one surefire intervention that can be used to prevent adverse cardiovascular events is to improve diet nutrition.
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