Improper DNA 'packaging' may be linked to schizophrenia
While scientists try to find newer ways to approach schizophrenia, individuals with the disease may be able to improve their lives if they buy Canadian Zyprexa.
While scientists try to find newer ways to approach schizophrenia, individuals with the disease may be able to improve their lives if they buy Canadian Zyprexa. Although a great number of studies have focused on looking for specific disease genes, new research from the Scripps Research Institute suggests that the cellular structures that package one's DNA may also be responsible for the illness' development.
In order to allow all of one's genetic material to fit within a cell, DNA is wrapped around proteins known as histones. These structures will reconfigure themselves as needed in order to allow the expression of different genes. This process is known as histone acetylation.
Based on previous research on Huntington's disease, the team of scientists wondered if schizophrenia may be tied to improper histone acetylation.
After studying brains that were donated to science, the researchers discovered that compared to healthy subjects, the cells of schizophrenics had lower levels of histone acetylation, which could block the expression of certain genes. Furthermore, this problems was more severe in younger patients, as published in the journal Translational Psychiatry.
"We're excited by the findings," said researcher Elizabeth Thomas, "and there's a tie to other drug development work, which could mean a faster track to clinical trials to exploit what we've found."
About 1.1 percent of American adults live with schizophrenia within any 12-month period, according to the National Institute of Mental Health.
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