Malaria drug may block inflammation associated with autoimmune disease
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Individuals who buy Celebrex may be able to relieve uncomfortable symptoms of osteoarthritis, such as pain, swelling and tenderness. This disease is characterized by inflammation, a process that could be blocked by the administration of chloroquine, a drug that has traditionally been used to treat malaria. This finding was the subject of a study conducted by researchers from the National Institute of Neurological Disorders and Stroke (NINDS).
Former NINDS chief Henry F. McFarland and his team reported that chloroquine has been used in the past as an anti-inflammation medicine for conditions like rheumatoid arthritis.
Numerous diseases involve inflammation, including asthma, Crohn's disease, multiple sclerosis, Guillain-Barre syndrome, myasthenia gravis, psoriasis and some cancers.
The researchers found that chloroquine suppresses the inflammatory process by activating a group of hormones known as glucocorticoids. This effect was mimicked by the inhibition of lysosomes in the cell, a finding that the team believes could pave the way to new strategies for treating autoimmune disorders.
"Researchers now have a clear path forward for undertaking projects to develop glucocorticoid and lysosome inhibitors," the scientists said.
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