Obesity and type 2 diabetes may result in difficulty conceiving
Many women who have type 2 diabetes buy Actos to help them achieve better glucose control.
Many women who have type 2 diabetes buy Actos to help them achieve better glucose control. A recent study published in the journal Public Library of Science One suggests that these ladies - as well as those who are obese - have high levels of saturated fatty acids in their ovaries, which could comprise the development of an embryo.
Lead researcher Jo Leroy and colleagues from the University of Antwerp conducted their study using a cow model. They believe that their findings can translate into humans and may explain why individuals who have metabolic disorders often struggle to conceive. According to the scientists, these women tend to metabolize more of their stored fat. This results in high concentrations of fatty acids in the ovary, which can be toxic for growing eggs prior to ovulation.
"In cows we can induce very similar metabolic disorders leading to reduced fertility in these animals and compromised egg quality in particular," Leroy explained. "This is one of the reasons that bovine eggs are a very interesting model for human reproductive research."
The researchers added that although the eggs were still able to enter the two-cell stage, they observed a notable reduction in those that were able to progress into blastocysts.
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