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Plaques, tangles associated with Alzheimer's may be linked to depression



Individuals who are coping with major depressive disorder can save money on medical bills if they buy Canadian Effexor at a fraction of what it costs in the U.S.

Individuals who are coping with major depressive disorder can save money on medical bills if they buy Canadian Effexor at a fraction of what it costs in the U.S. People who are at risk for this mental illness include the elderly, and new research from the University of California, Los Angeles, indicates that the underlying cause may be the same amyloid plaques and tau tangles that are associated with Alzheimer's disease.

Past studies suggested that in addition to spurring dementia, amyloid plaques and tau tangles may also cause mild depression and anxiety for some older people, researchers said. In order to investigate further, a team of scientists conducted an experiment with 39 subjects aged 60 to 82 years: 20 had major depressive disorder, while the rest acted as healthy controls.

The scientists used a chemical marker known as FDDNP, which reveals amyloid plaques and tau tangles in PET scans of the brain. Results showed that these abnormal protein formations were present in greater amounts in the subjects who had depression, binding in particular to parts of the brain that control emotions, memory and other functions, as published in the journal Archives of General Psychiatry.

Successful use of FDDNP in this experiment may enable doctors to track the development of neurodegenerative symptoms in seniors, as well as how well certain treatments may work, according to the researchers.

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