Researchers identify the 'brakes' of breast cancer
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Breast cancer patients who are eager to live as functional a life as possible can buy Canadian Tamoxifen to help. Scientists are also searching for new ways to stop malignancies from growing. Research from McGill University's Goodman Cancer Research Centre have identified one gene that may serve as the "brakes" for this disease.
Clinical observation had demonstrated that the gene 14-3-3-sigma is inactive in many cases of breast cancer, leading a team of scientists to investigate its role in the development of the disease.
The researchers bred a mouse model of breast cancer that expressed ErbB2, a gene associated with malignancies of the breast. In the lab, the team inactivated 14.-3-3-sigma in the mammary glands of these mice, as published in the journal Cancer Discovery.
"We found that the loss of this expression did, in fact, result in a dramatic acceleration of tumor onset," said researcher William Muller. "The two genes, 14-3-3-sigma and ErbB2, co-operate, with 14-3-3-sigma being the brakes. If you lose the brakes, ErbB2 can induce the cells to divide indefinitely."
The loss of 14-3-3-sigma can also allow breast cancer cells to invade other parts of the body, Muller added. This study may provide researchers a new therapeutic target.
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