Scientists explore mechanism behind function of AADs
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Buying cheap medication from Canada can help individuals with a variety of health conditions save money on the products they need to stay well. Recently, researchers from the University of British Columbia identified the mechanism behind anti-arrhythmic drugs (AADs), which are used to treat irregular heartbeats.
The paper, which was published in the journal Nature Communciations, revealed that AADs are categorized based on how they affect the electrocardiogram, not on their inherent qualities. This may limit researchers' ability to improve these drugs, according to lead author Chris Ahern and his colleagues in the department of anesthesiology, pharmacology and therapeutics.
"By understanding how these drugs work at the molecular level, we will be better able to pick and choose the traits we want - and those we don't - when developing new drugs for this dangerous condition," said Ahern.
The team introduced various alterations of artificial amino acids to mirror the behavior of the cardiac sodium channel, which is where AADs bind in the human body. They identified several trends among the different classes of these substances, which could help drug developers better isolate the most beneficial qualities of each product, according to the scientists.
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