Study reveals the role of two brain receptors in schizophrenia
People who struggle with the mental illness schizophrenia can buy Canadian Zyprexa to help control hallucinations and other symptoms that keep them from living a functional life.
People who struggle with the mental illness schizophrenia can buy Canadian Zyprexa to help control hallucinations and other symptoms that keep them from living a functional life. Other drugs, such as clozapine, may also be helpful, but can have side effects that alter glucose control as well as the immune system. However, research from Mount Sinai School of Medicine may lead to the development of more efficient medications.
Based on previous research that indicated that the glutamate mGlu2 receptors and the serotonin 5-HT2A receptors in the brain played major roles in schizophrenia, the scientists conducted a laboratory experiment to determine the effects of both anti-psychotic drugs and hallucinogens on these systems.
Results showed that anti-psychotics increased activity in the glutamate receptors and decreased activity in the serotonin receptors. However, hallucinogens had the opposite effect. These modifications in receptor behavior correspond to what is observed in the brains of healthy individuals and patients with schizophrenia, as published Nov. 23 in the journal Cell.
"Now that we know how current drugs affect the ratio of activity in this glutamate-serotonin receptor complex, we can try to identify or develop more effective treatments for schizophrenia that result in a healthier signaling ratio," said researcher Javier Gonzalez-Maeso, PhD.
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