Type 2 diabetes and Alzheimer's disease are connected by the SorCS1 gene
Many patients who have type 2 diabetes are often advised to buy Actos to help improve their blood glucose control.
Many patients who have type 2 diabetes are often advised to buy Actos to help improve their blood glucose control. Recently, research presented at the Annual International Conference of the Alzheimer's Association in Paris, France, revealed that the metabolic disorder may be linked to cognitive impairment.
Lead author Sam Gandy and colleagues from the Alzheimer's Disease Research Center at the Mount Sinai School of Medicine reported that a gene called SorCS1 controls the generation of amyloid-beta plaques in the brain, which are characteristic of the neurodegenerative disease.
According to the researchers, SorCS1 may also contribute to the development of type 2 diabetes. The gene apparently controls the movement of amyloid precursor protein, which influences the amount of amyloid-beta being created by cells.
"The great thing about studying SorCS1 is that we already have entirely new ideas about how to treat both Alzheimer's disease and type 2 diabetes," Gandy explained. "Our hunch is that SorCS1 also controls how the insulin receptor moves around the cell, but we have not yet proven that."
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